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Lycium barbarum L.-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Engineering doi: 10.1016/j.eng.2023.09.007

Abstract: Bioinformatics prediction and luciferase reporter assay identified that miR162a targeted nuclear receptorcorepressor (NcoR).

Keywords： Traditional Chinese medicine     Lycium barbarum     L     miR162a     Osteoporosis     Nuclear receptor corepressor     Transgenic    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Special issue: innovative nuclear energy technology

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 791-792 doi: 10.1007/s11708-021-0794-4

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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An old issue and a new challenge for nuclear reactor safety

F. D’AURIA

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 854-859 doi: 10.1007/s11708-021-0729-0

Abstract: Nuclear reactor safety (NRS) and the branch accident analysis (AA) constitute proven technologies: theseamong the other things, long lasting research and operational experience in the area of water cooled nuclearWeaknesses became evident, noticeably in relation to nuclear fuel under high burn-up.

Keywords： large break loss of coolant accident (LBLOCA)     nuclear reactor safety (NRS)     licensing perspectives     basisfor design of water cooled nuclear reactors (WCNR)    

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Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Abstract Chimeric antigen receptor T cell (CAR T) therapies have achieved unprecedented efficacy in B-cell

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

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Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 57-68 doi: 10.1007/s11684-019-0683-y

Abstract: In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-TEpidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation expressed in various

Keywords： chimeric antigen receptor T cells     epidermal growth factor receptor     lung cancer     immunotherapy     tumor immunolog    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression can
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Let Nuclear Technology Create New Brilliancy forChina’s Sustainable Development

Du Xiangwan

Strategic Study of CAE 2008, Volume 10, Issue 1,   Pages 9-11

Abstract:

This paper summarizes the development and application directions of nucleartechnology, including five aspects: nuclear technology and energy、nuclear technology and medicine,nuclearanalysis technology,nuclear radiation technology,astronautics and voyage´s nuclear power,etc.discusses the importance of them to sustainable development and generalizes the development trilogy of nuclear

Keywords： nuclear science     nuclear technology     nuclear engineering     sustainable development    

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Reliability prediction and its validation for nuclear power units in service

Jinyuan SHI,Yong WANG

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 479-488 doi: 10.1007/s11708-016-0425-7

Abstract: In this paper a novel method for reliability prediction and validation of nuclear power units in serviceUsing these factors, the equivalent availability factor of nuclear power units in the following 3 yearsFurthermore, the reliability prediction method is validated using the nuclear power units in North AmericanIt is found that the relative errors of the predicted equivalent availability factors for nuclear powerfollowing 3 years, thus providing effective reliability management and maintenance optimization methods for nuclear

Keywords： nuclear power units in service     reliability     reliability prediction     equivalent availability factors    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isa cell surface receptor expressed on monocytes/macrophages and neutrophils.

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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A Chinese–French Study on Nuclear Energy and the Environment Feature Article

Xiangeng Zhao, Qizhen Ye, Sébastien Candel, Dominique Vignon, Robert Guillaumont

Engineering 2023, Volume 26, Issue 7,   Pages 159-172 doi: 10.1016/j.eng.2023.04.011

Abstract:

This article focuses on the environmental impact of nuclear energy andaddresses the following major environmental issues associated with nuclear power generation: ① controllingaccidents and their radioactive releases and; ④ improving nuclear safety to restrict its environmentalimpact and to contribute toward the public acceptance of nuclear energy.The annual effective radiation dose delivered to the public surrounding nuclear power plants under normal

Keywords： Nuclear energy     Environmental impact     Radwaste management     Severe nuclear accidents     Nuclear safety    

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Sustainable Development of Chinses Nuclear Power

Zhao Renkai

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 33-41

Abstract:

Nuclear power is considered a sustainable energy resource, and it is a very important pillar for theIn the paper, the present status of nuclear power development in the world and China is described.The general and specific policies and technical route for Chinese nuclear power development, and severalproblems commonly concerned with Chinese nuclear power development, such as uranium resources、nuclearsafety、radioactive wastes and localization of nuclear power in China are expounded and analyzed.

Keywords： nuclear energy     uranium resources     nuclear safety     radioactive westes     localization    

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Title Author Date Type Operation

Lycium barbarum L.-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Special issue: innovative nuclear energy technology

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Journal Article

An old issue and a new challenge for nuclear reactor safety

F. D’AURIA

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Let Nuclear Technology Create New Brilliancy forChina’s Sustainable Development

Du Xiangwan

Journal Article

Reliability prediction and its validation for nuclear power units in service

Jinyuan SHI,Yong WANG

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

A Chinese–French Study on Nuclear Energy and the Environment

Xiangeng Zhao, Qizhen Ye, Sébastien Candel, Dominique Vignon, Robert Guillaumont

Journal Article

Sustainable Development of Chinses Nuclear Power

Zhao Renkai

Journal Article